Date of Award
Spring 2019
Degree Type
Honors Project
Department
Chemistry/Biochemistry
First Advisor
Zeb Kramer, Ph.D.
Second Advisor
Vincent Kling, Ph.D.
Abstract
Previous research provides experimental evidence that cantharidin acts as an inhibitor of HSF1 in cancer cells whereas the similar norcantharidin exhibits no inhibitory activity on HSF1. This computational study utilized Autodock to suggest both binding site(s) and binding energies of cantharidin and norcantharidin on HSF1. This study found cantharidin to consistently bind stronger than norcantharidin in the same area on HSF1 when assuming a rigid protein structure.
Recommended Citation
Coyle, Daniel, "Ligand-Protein Binding of Cantharidin and Norcantharidin on HSF1: A Docking Study" (2019). HON499 projects. 23.
https://digitalcommons.lasalle.edu/honors_projects/23
Included in
Medicinal-Pharmaceutical Chemistry Commons, Other Chemistry Commons, Physical Chemistry Commons