Date

Spring 2019

Document Type

Honors Project

Department

Chemistry/Biochemistry

First Advisor

Zeb Kramer, Ph.D.

Second Advisor

Vincent Kling, Ph.D.

Abstract

Previous research provides experimental evidence that cantharidin acts as an inhibitor of HSF1 in cancer cells whereas the similar norcantharidin exhibits no inhibitory activity on HSF1. This computational study utilized Autodock to suggest both binding site(s) and binding energies of cantharidin and norcantharidin on HSF1. This study found cantharidin to consistently bind stronger than norcantharidin in the same area on HSF1 when assuming a rigid protein structure.

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